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Neuroscientist, Preclinical Electrophysiology

Axoft
Posted a day ago
Location

Cambridge, MA, US

Salary

$110,000 - $125,000 per year

Contract type

Full Time

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About Axoft:聽

Axoft develops ultrasoft, implantable brain鈥搈achine interfaces designed for minimally invasive implantation and stable, high-bandwidth communication with the brain. Our team brings together expertise in neuroscience, engineering, and materials science to develop neural interfaces for people with neurological disorders.

About the Role:

We are seeking a Neuroscientist to plan and perform neural implant surgeries, develop behavioral tasks for animal studies, and collect electrophysiology data from implanted neural interfaces. You will collaborate with Axoft鈥檚 engineering teams, animal research facility staff, and contract research organizations (CROs) to run studies and resolve experimental issues. You will assess signal quality during recordings and work with colleagues who lead downstream data analysis. The role might require flexible business hours and ability to travel abroad multiple times a year.

Key responsibilities:

路聽聽聽聽聽聽Plan and coordinate neural implant surgeries with animal research facilities and CROs. Manage the surgical schedule and confirm that staff, equipment, and supplies are ready before each procedure.

路聽聽聽聽聽聽Perform neural implant surgeries in collaboration with veterinary and facility staff. Document procedures, deviations, and follow-up actions.

路聽聽聽聽聽聽Identify and evaluate solutions to surgical challenges to develop new surgical procedures and improve existing ones, with input from our clinical neurosurgery advisors.聽

路聽聽聽聽聽聽Design, pilot, and refine behavioral tasks to meet neuroscience study objectives. Develop animal training procedures as needed and track behavioral performance across sessions.

路聽聽聽聽聽聽Set up and run聽in vivo聽electrophysiology sessions, including repeated recordings for longitudinal studies. Assess signal quality during acquisition, identify noise and artifacts, troubleshoot recording issues, and document session conditions for the analysis team.

路聽聽聽聽聽聽Write and maintain study protocols and experimental procedures. Communicate study progress and technical issues to collaborators.

Required qualifications

  • Ph.D. in systems neuroscience, biomedical engineering, neuroengineering, electrophysiology, or a related field.

  • At least three years of relevant academic or industry experience in聽in vivo聽animal research.

  • Extensive hands-on experience in animal neurosurgery, including independently implanting neural electrodes or other neural devices in research animals.

  • Hands-on experience acquiring聽in vivo聽electrophysiology data with implanted multielectrode arrays (e.g. Neuropixels) and the ability to recognize expected neural signals (spikes, local field potential) and common recording artifacts.

  • Experience debugging and denoising electrophysiology recording hardware outside of optimized laboratory environments.

  • Experience designing or adapting behavioral tasks and conducting behavioral testing in research animals.

  • Strong attention to detail in surgical preparation, adherence to study protocols, and documentation of procedures and recording sessions.

  • Strong communication skills and the ability to collaborate across scientific and engineering teams.

Preferred qualifications

路聽聽聽聽聽聽聽Experience with electrical neural stimulation using microelectrodes, including designing stimulation paradigms or selecting stimulation parameters, and characterizing single-cell and local neural responses to stimulation.

路聽聽聽聽聽聽聽Surgical experience with pigs, nonhuman primates, or other large-animal models.

路聽聽聽聽聽聽聽Experience with neural tissue histology, such as tissue preparation, sectioning, staining, or microscopy. Experience evaluating implant sites or tissue responses to neural implants is a plus.

路聽聽聽聽聽聽聽Experience developing surgical protocols and coordinating preclinical studies with external animal research facilities or CROs.

路聽聽聽聽聽聽聽A record of peer-reviewed publications in neuroscience, neuroengineering, or a related field, ideally involving聽in vivo聽electrophysiology, animal behavior, or implantable neural interfaces.

路聽聽聽聽聽聽聽US driving license.聽

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