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Principal Associate Scientist, Discovery & Translational Development – Solid BiosciencesÂ
Charlestown, MA
Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care.
Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases.
We are seeking a highly skilled and motivated bench scientist to join the Discovery & Translational Development team to support our clinical and pre-clinical programs. The ideal candidate will have a strong scientific background in mammalian cell culture, assay development, and molecular biology. Reporting to the Senior Principal Scientist, Scientific Lead, this is an on-site position based out of Solid’s headquarters in Charlestown, MA.
Responsibilities
Technical Execution
- Develop AAV functional potency assays by transfecting, transducing, and/or engineering mammalian cell lines
- Develop molecular assays (ddPCR, ProteinSimple Jess) and cell-based assays to assess expression cassettes and AAV potency
- Develop ELISA and MSD assays to identify novel biomarkers using patient and nonclinical samples
- Support oversight and review or CRO activities
- Maintenance of electronic lab notebook (ELN) documenting experimental procedures, materials, reagents, and data
- Data Analysis: Independently analyze experimental data accurately and efficiently, drawing valid conclusions.
- Lab Maintenance: Ensure proper maintenance of laboratory equipment and ensure a safe working environment.
Cross-Functional Support
- Collaborative Projects: Participate in projects across different programs, providing expertise where needed.
- Knowledge Sharing: Share findings and methodologies with peers to foster a collaborative environment. Provide guidance/mentorship to junior scientists.
- Flexibility: Adapt to shifting priorities and contribute to multiple projects as required.
Compliance and Quality Assurance
- Regulatory Compliance: Conduct all activities in accordance with regulatory guidelines and company policies.
- Quality Standards: Ensure all experimental procedures meet quality standards.
- Documentation: Maintain accurate and detailed records of all experiments and results.
Communication
- Reporting: Communicate progress and results to scientific leads and team members regularly.
- Team Meetings: Participate actively in team meetings, providing updates and insights. Effective communication and interpretation of complex scientific subjects to all audiences.
- Interpersonal Skills: Build positive working relationships within the team and across the organization. Apply learnings from the broader organization as they relate to the project team.
Required Qualifications
- MS in Biology or related discipline with 5+ years of industry experience or BS with 7+ years of industry experience
- Background in Friedreich’s ataxia and mitochondrial biology is preferred
- Proficiency with mammalian cell culture, cell line engineering, and/or iPSC differentiation, and experience with transfection or AAV transduction
- Proficient in quantitation of DNA, RNA, and protein expression by ddPCR, qPCR, ProteinSimple Jess, ELISA, and MSD
- Software proficiency including Geneious, SnapGene, NCBI, BLAST, Ensembl, GraphPad Prism, Benchling, and Microsoft Office Suite
- Ability to work independently and collaboratively
- Strong organizational, written, and verbal communication skills
CompensationÂ
The base compensation range for this role is: $110,000 – 125,000
Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance.
Benefits and Solid AdvantagesÂ
At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees’ lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices.
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