Site: The General Hospital Corporation

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

The Massachusetts General Hospital Cancer Center’s Process Development Laboratory seeks a full-time Process Development Scientist I to support and advance its translational cell and gene therapy research platform. The Process Development Laboratory is a highly integrated, innovation-driven facility dedicated to translating next-generation cellular immunotherapy and gene engineering technologies into clinically deployable manufacturing solutions. This position offers an exceptional opportunity for an independent and motivated scientist to serve as a scientific lead within a multidisciplinary translational team, working at the interface of biology, engineering, manufacturing science, and regulatory strategy. The successful candidate will contribute to the design, development, optimization, and clinical translation of novel manufacturing workflows poised for IND-enabling studies and early-phase clinical trials, while operating in a collaborative academic medical center environment.

Job Summary

In consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication. Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary.

Does this position require Patient Care? No

Essential Functions
-Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field.

-Contributes to the design and execution of experiments and/or research projects.

-Exercises judgment in selecting methods and technologies to obtain results.

-May collaborate with external researchers and/or receive external project funding support.

-Presents results and prepares publications.

-May assist PI in the training and supervision of other staff.

Qualifications

Job Description

Education Doctorate Related Field of Study required

Can this role accept experience in lieu of a degree? No

Licenses and Credentials

Experience
Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required

Knowledge, Skills and Abilities
- Excellent research skills.
- Demonstrated evidence of specific scientific competence in field.
- Demonstrated broad knowledge of field.
- Evidence of potential for scientific creativity and original though.
- Able to exercise independent judgment and leadership.
- Ability to contribute to publications.

Additional Job Details (if applicable)

Preferred Qualifications:

· Demonstrated experience in cell and/or gene therapy research and process development.

· Hands-on experience working with primary human cells, preferably immune effector cells.

· Strong foundation in cell culture, molecular biology, and translational experimental design.

· Experience with CAR T-cell or immune effector cell manufacturing.

· Familiarity with CRISPR/Cas-based genome editing technologies.

· Experience with viral vector production or gene delivery platforms.

· Exposure to cGMP environments, IND-enabling studies, or regulated manufacturing settings.

· Experience with closed-system or automated manufacturing platforms.

· Prior experience contributing to regulatory documentation, technology transfer, or validation activities.

Remote Type

Onsite

Work Location

149 Thirteenth Street Building 149

Scheduled Weekly Hours

Employee Type

Regular

Work Shift

Day (United States of America)

EEO Statement:

1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

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Research Scientist [PDL Lab]

Mass General Brigham Competency Framework