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Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
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Job Summary
The Kleinstiver Laboratory (www.kleinstiverlab.org) in the Center for Genomic Medicine (CGM) at Massachusetts General Hospital (MGH) is seeking a motivated, enthusiastic candidate to join our research group.Our research group engineers and optimizes genome editing technologies to apply them for biomedical research and to treat human diseases. We pursue protein and nucleic acid engineering methods to impart desirable properties into CRISPR-Cas enzymes to develop technologies capable of installing single letter DNA edits (e.g. base editors), for DNA writing approaches (e.g. prime editors, click editors, etc.) that can install a variety of short NDA edits, for various editors capable of larger sequence edits (e.g. CRISPR-associated transposases (CASTs), transposons, recombinases, etc.), and other non-CRISPR editing platforms. Examples of key properties of these classes of enzymes that we seek to optimize include efficiency (on-target activity), safety (reducing off-target activity), versatility and programmability (targeting range / ability to access the genome), precision (their edit outcomes), and other characteristics. Optimized proteins are developed via rational design, directed evolution, structure-guided engineering, machine learning, and additional approaches. We then deploy these optimized tools in pre-clinical studies using animal models and primary human cells, assessing their potential to correct pathogenic mutations for a diverse set of diseases including liver-based disorders, inborn errors of immunity, neurological and neuromuscular, deafness, and others.
The candidate will play an integral role in managing the laboratory and projects related to genome editing technology development, protein engineering method development, and expediting the clinical application of these tools. Candidates will ideally have interests in genome engineering, technology development, the creation of genetic medicines, and other related fields.
Please note, the functions below are representative of major duties that are typically associated with these positions. Specific responsibilities may vary based upon departmental needs. Similarly, not all duties that have been outlined will be assigned to each position.
Does this position require Patient Care? No
Essential Functions:
-Responsible for oversight of all lab supply and equipment, purchasing and maintenance.
-Coordinates all regulatory and compliance activities.
-Trains staff in specialized lab techniques.
-Assists with subject scheduling.
-Provides input on strategy, based on knowledge of industry and trends.
-Applies project management techniques to ensure development initiatives stay on track.
-Contributes to scientiļ¬c literature and may present the data at meetings.
-Carries out independent research projects which involve the execution of highly sophisticated techniques.
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Qualifications
Education
Bachelor's Degree Related Field of Study required or Master's Degree Related Field of Study preferred
Can this role accept experience in lieu of a degree?
Yes
Licenses and Credentials
Experience
Research experience (in a lab setting) 3-5 years required
Knowledge, Skills and Abilities
- Must be able to make independent, effective decisions in appropriate situations.
- Must possess a scientific imagination commensurate with the independent execution of research projects.
- Must have an aptitude for technical problem solving.
- Excellent organizational skills to ensure smooth functioning of lab.
- Demonstrated analytical skills and ability to logically sequence experiments to maximize research.
- Must possess an aptitude for budget management.
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Additional Job Details (if applicable)
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Remote Type
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Work Location
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Scheduled Weekly Hours
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Employee Type
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Work Shift
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Pay Range
$63,252.80 - $102,596.00/Annual
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Grade
7
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EEO Statement:
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Mass General Brigham Competency Framework
At Mass General Brigham, our competency framework defines what effective leadership ālooks likeā by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
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