SAP S/4HANA Manufacturing Systems Specialist

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!  

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics. 

Why Join Us? 

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy. 

• Collaborative Culture: Be part of a diverse team dedicated to your professional growth. 

• Global Impact: Contribute to therapies that make a lasting impact on patients globally. 

We are seeking an SAP S/4HANA Manufacturing Technical & Functional Specialist to support our US Computer Systems Validation team. The SAP S/4HANA Manufacturing Technical & Functional Specialist is responsible for configuring, supporting, and optimizing SAP S/4HANA manufacturing solutions in a regulated (GxP) environment. This role partners closely with manufacturing business users, SAP developers, engineering, and validation teams to deliver compliant, efficient, and scalable manufacturing processes. The position requires a strong combination of SAP manufacturing configuration expertise, Engineering Change Management (ECM) experience, technical collaboration skills, and experience working within validated SAP landscapes. 

FLSA Classification: Salary, Exempt  
Schedule: 8:00 AM – 5:00 PM; Monday to Friday; On-site  
Reports to: ERP Manager  
Location: 13203 Murphy Road Suite 100 Stafford, TX 77477  

What You’ll Do: 

As an SAP S/4HANA Manufacturing Technical & Functional Specialist, you will play a key role in supporting our Computer Systems Validation team:  

• Configure and support SAP S/4HANA manufacturing processes, primarily with integration to Extended Warehouse Management (EWM), Materials Management (MM) and Quality Management (QM). 

• Maintain and support manufacturing master data including BOMs, routings, work centers, production versions, and production orders. 

• Support Engineering Change Management (ECM) processes, including configuration and management of engineering changes impacting BOMs, routings, and production data. 

• Ensure engineering changes are properly assessed, documented, approved, and implemented in SAP in alignment with change control and validation requirements. 

• Translate manufacturing and engineering business requirements into clear functional and technical specifications. 

• Collaborate with SAP developers on custom developments, enhancements, interfaces, and integrations related to manufacturing and ECM processes. 

• Support SAP Computer System Validation (CSV) activities, including impact assessments, testing, and documentation in compliance with GxP requirements. 

• Partner with validation and quality teams to ensure all system and engineering changes meet regulatory and audit standards. 

• Provide production support, issue resolution, and root cause analysis for manufacturing- and engineering-related SAP issues. 

• Support system upgrades, enhancements, and continuous improvement initiatives within SAP S/4HANA manufacturing. 

Required Experience and Education: 

• Bachelor’s degree in IT, Engineering, Manufacturing, or a related field, or equivalent experience. 

• Minimum of 5 years of hands-on experience working in SAP S/4HANA environments 

• Hands-on experience configuring SAP S/4HANA manufacturing solutions. 

• Experience supporting Engineering Change Management (ECM) processes and Master data Updates within SAP. 

• Experience working with SAP developers on technical solutions and system integrations. 

• Experience supporting SAP systems in regulated (GxP) environments with validation requirements. 

• Strong understanding of end-to-end manufacturing and engineering processes. 

Preferred Experience and Education:  

• Experience in pharmaceutical, biotech, medical device, or other regulated manufacturing industries. 

• Experience with SAP ECC to S/4HANA manufacturing migrations. 

• Knowledge of shop floor integration, MES, or manufacturing execution systems. 

Competencies  

• Strong SAP S/4HANA manufacturing functional and technical expertise 

• Solid understanding of Engineering Change Management (ECM) and change control processes 

• Effective cross-functional communication and collaboration 

• Strong analytical and problem-solving skills 

• High attention to detail and documentation discipline 

• Ability to operate effectively in a validated, audit-ready environment 

Work Environment:  

This is a sedentary position (at least 50% of time) in a typical office environment. There may be frequent interruptions with moderate noise levels and frequent use of printers, copiers, scanners, computers and other office equipment. Ability to sit, talk, walk, hear and communicate verbally and in writing is required. Occasional lifting of objects up to 25 lbs is expected.  

Travel required: up to 10%, including nationally and internationally. 

Physical demands: 

• Communicating Verbally – expressing or exchanging ideas by means of the spoken word to impart oral information to others to convey detailed spoken instructions or other workers accurately, loudly or quickly. 

• Hearing – the ability to hear, understand, and distinguish speech and/or other sounds one-on-one, group or conference, telephone, and other sounds. 

• Keyboarding – entering data or text into a computer or other machine by means of a keyboard. Devices include a traditional keyboard, 10 key-pad, touch screens and others.  

• Lifting - raising or lowering an object (up to 25 lbs) from one level to another (includes upward pulling). Carrying is to transport an object – usually by holding it in the hands or arms but may occur on the shoulder. 

• Near Visual Acuity – clarity of vision at approximately 20 inches or less (working with small objects, reading small print, including the use of computers).  

• Pushing - Exerting force upon an object so that the object moves away from the object. 

• Pulling - Exerting force upon an object so that the object moves toward the force.  

• Sitting – remaining in a sitting position for at least 50% of the time. 

• Standing/Walking - remain on one's feet in an upright position at a workstation.  

• Stooping – occasional bending the body downward and forward by bending the spine at the waist - requiring full use of the lower extremities and back muscles. 

Work authorization/security clearance requirements:  

Legal eligibility to work in the United States is required. Immatics participates in E-Verify and all new employees will be subject to the Department of Homeland Security requirements for employment   

Affirmative Action/EEO statement:   

Immatics is an equal opportunity employer. All employment decisions including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs.  

What do we offer?  

At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join Immatics 

Comprehensive Benefits:  

• Competitive rates for Health, Dental, and Vision Insurance 

• 4 weeks of Paid Time off, granted up front each year and prorated for first and last year of employment. 

• Sick Time Off – 56 hours  

• 12 Paid Holidays  

• 100% Employer-Paid Life Insurance up to at 1x annual salary, up to 100K ( club together) 

• 100% Employer Paid Short- and Long-Term Disability Coverage  

• 401(k) with Immediate Eligibility  & company match… 

• You are eligible for 401(k) plan participation as of your first paycheck. 

• The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment. 

• Partially paid Parental Leave for eligible employees. (3 weeks) 

• Additional voluntary employee paid coverages including  Accident, Hospital Indemnity, and Critical Illness Employee Paid Identity Theft Protection and Pet Insurance.  

Professional Growth:  

• Opportunities to work with leading experts in the field of T-cell immunotherapy.  

• Company provided learning and development opportunities 

• Fast paced, high demand collaborative and dynamic environment.