Research Assistant (Clinical Genetic)- MORL

Summary:

The Molecular Otolaryngology and Renal Research Laboratories, within the Department of Otolaryngology, is seeking a Research Assistant (RA). The lab utilizes molecular and cytogenetic techniques, including PCR, Sanger sequencing, multiplex ligation-dependent probe amplification (MLPA), next-generation sequencing (NGS) and targeted genomic massively parallel sequencing for diagnostic testing of genetic hearing loss and rare complement-mediated renal disease. In this role, the RA will perform components of cytogenetic and molecular studies according to established laboratory protocols and work to maintain and improve the clinical testing environment, capabilities, and quality of data in the laboratory. This position is first shift (8am – 5pm) Monday through Friday.

Responsibilities:

• Perform high complexity testing on clinical biological specimens such as blood, saliva, and DNA.
• Able to properly manage time based on established priorities.
• Perform appropriate documentation and maintain accurate and legible records.
• Perform routine quality control, maintenance, calibration, and assist in troubleshooting of laboratory instruments.
• Evaluate quality control results and initiate corrective action when QC metrics are not acceptable.
• Maintain inventory and order supplies as needed.
• Perform a variety of molecular biology procedures that may include:
• DNA extraction
• Processing DNA for applications including PCR and next generation sequencing (NGS)
• Begin and ensure proper execution of analytic pipelines for both Sanger and NGS clinical tests.
• Accept and apply feedback in a positive, constructive manner.
• Assist in a positive and professional manner with wet-bench training for other laboratory colleagues within the section.
• Participate in lab section meetings with others to discuss quality testing, workflow, efficiency strategies, problematic areas, and laboratory improvement.
• Maintain effective working relationships with faculty, staff, students, and the public.
• Ability to work with a variety of individuals and groups in a constructive and civil manner while appreciating the unique contribution of individuals from varied cultures, nationalities, genders, ages, etc.
• Ability to utilize existing resources and learning to achieve or exceed desired outcomes of current and future organizational goals/needs. Able to demonstrate ethical behavior in a variety of situations while producing results.
• Ability to meet or exceed customer service needs and expectations and provide excellent service in a direct or indirect manner. Ability to effectively transmit and interpret information through appropriate communication with internal and external customers.

Required Qualifications:

• A bachelor’s degree or an equivalent combination of education and experience. Preference: Microbiology, Biology, Genetics or Similar
• Over 2 years’ experience with project coordination including time management, decision making, and self-direction in microbiology, biology, chemistry, or a similar discipline.
• Excellent organizational, interpersonal, and communication (both verbal and written) skills.
• Experience preparing solutions and purchasing supplies.
• Demonstrated experience with DNA quantification using established protocol including spectrophotometer and fluorometric methods .
• Willingness to learn relevant lab protocols under supervision of the principal investigator and other staff.
• Proficiency in computer software applications, including Microsoft Office Suite and LIMS.
• Ability to analyze information and situations, prioritize tasks, and develop solutions to challenges.
• Ability to use good judgment while working independently and in a team setting.
• Experience in general laboratory upkeep such as sample inventory, biohazard waste management, and autoclave use.

Desired Qualifications:

• Greater than two years of demonstrated experience working in either a clinical laboratory and/or a molecular research laboratory.
• A bachelor’s degree in a genetic, biological, or clinical laboratory sciences or related field is highly desirable.
• Experience developing primers, amplimer validation, and protocol development
• Demonstrated experience with molecular biology techniques including PCR and Sanger sequencing.
• Experience evaluating genetic variants for significance using computational methods
• Knowledge of next generation sequencing (NGS) technologies is highly desirable.
• Knowledge of EHS, OSHA, and HIPAA compliance standards in a laboratory setting.
• Understanding of clinical testing conduct as outlined in a testing protocol is desirable.
• Demonstrated ability to resolve issues related to healthcare provider concerns or workflow changes and challenges.

• Experience managing large data sets and maintaining highly organized and detailed data records.

   

Position and Application Details

In order to be considered for an interview, applicants must upload the following documents and mark them as a “Relevant File” to the submission:

• Resume
• Cover Letter

Job openings are posted for a minimum of 7 calendar days and may be removed from posting and filled any time after the original posting period has ended.

Successful candidates will be required to self-disclose any conviction history and will be subject to a criminal background check and credential/education verification. Up to 5 professional references will be requested at a later step in the recruitment process.

For additional questions, please contact ashley-rayer@uiowa.edu.