Clinical Research Manager Licensed (RN) - Medicine Clinical Trials Office

The Clinical Research Manager Licensed has oversight of the research projects within a department or division. Assists the Principal Investigator (P.I.) in preparing and negotiating clinical trials care delivery, patient eligibility, budgets, adequate staffing and all related HR activity.

The Clinical Trials Office is seeking a highly skilled Clinical Research Nurse manager to lead and support and support a growing portfolio of cellular therapy clinical research, with primary focus on non-malignant CAR-T and cellular therapy studies, while providing transitional collaboration of malignant Bone Marrow Transplant (BMT)/Cellular Therapy programs. 

This role will initially focus on the coordination and implementation of complex clinical research studies involving CAR-T cell therapy and non-malignant cellular therapy (50% effort) and support of malignant Bone Marrow Transplant (BMT/Cellular Therapy) activities for 50% effort. Over time, the non-malignant effort will grow, and the malignant effort will decrease. The role will ensure participant safety, protocol adherence, and regulatory compliance while collaborating with principal investigators and multidisciplinary teams to achieve successful study execution and maintain data integrity. 

This role involves direct patient interaction, ensuring the safety and well-being of study participants, adhering to study protocols, and maintaining regulatory compliance. This position is ideal for a highly organized professional who thrives in a fast-paced environment and excels at managing complex workflows, regulatory documentation, and multi-study coordination. Under minimal supervision, the Clinical Research function includes studies of increased complexity. The position features a dual reporting structure to Tisch Cancer Institute and to Departmental Clinical Research teams with and without nursing licensure, requiring strong communication and adaptability. Responsibilities and assigned program areas may evolve over time based on departmental programmatic needs. 

This role is critical to supporting the strategic expansion of non-malignant cellular therapy research while maintaining excellence in clinical care, regulatory compliance, and operational efficiency. The Nurse Manager will play a central role in scaling innovative therapies, leading teams, and ensuring successful study execution across a growing and complex portfolio.

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

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About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

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The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.