Uniquity Bio is a clinical-stage biotechnology company committed to putting science and patients first. We exist to develop transformative new medicines for immune-mediated diseases, and we’re looking for bright-minded professionals driven by a desire to advance science and make a difference for people in need. Our lead asset, solrikitug, is a highly-potent TSLP inhibitor now in Phase 2 clinical trials for asthma, chronic obstructive pulmonary disease (COPD), and eosinophilic esophagitis (EoE) indications.

Join us in building an organization where people and science thrive together. You’ll have the opportunity to make a meaningful impact while working alongside a talented, agile team in an environment where ideas move quickly, colleagues are trusted, and quality remains a cornerstone.

Position Overview

The Director of Translational Medicine will report directly to the Vice President of Translational Medicine and Early Development and work closely with cross-functional members of the Uniquity organization (e.g. Clinical, regulatory, clinical pharmacology, product strategy, project management) to provide scientific leadership for translational studies across respiratory and gastrointestinal programs. The Director will design, manage, and interpret external academic collaborations and CRO run studies, translate mechanistic competitive intelligence into experimental and clinical insight, and support clinical biomarker strategy development and execution. The Director will also support internal mechanism training and external communication of translational studies.

Key Responsibilities

Design, oversee, and interpret external CRO-run translational research studies that establish mechanism-of-action for early and late-stage programs (protocol development, study design, data review, and interpretation).
Collaborate with external academic partners and KOLs — establish study aims, ensure scientific rigor, manage timelines and deliverables, and maintain strong scientific relationships.
Critically review experimental design and methodology across programs to ensure robustness, reproducibility, and appropriate statistical considerations.
Provide mechanistic interpretation of competitive intelligence across respiratory and GI immunology & inflammation (I&I) programs; translate competitor biology and data into implications for our assets and experimental plans.
Support evaluation and provide scientific rationale for future indication expansion opportunities
Support clinical biomarker activities including sample management, assay selection, vendor selection and management, QC, and data integration from clinical studies.
Communicate translational findings clearly to cross-functional partners (e.g. clinical, non-clinical, regulatory, commercial, and leadership) and contribute to regulatory/clinical briefing materials as needed.

Qualifications

PhD in immunology or closely related field
Expertise in eosinophil biology or type 2 inflammation in respiratory or GI diseases is preferred
Minimum 6+ years of relevant experience in translational medicine/research, early-stage development or pharmacology in biotech/pharmaceutical drug development
Proven track record designing and interpreting translational studies (in vitro, in vivo, and clinical biomarker work).
Experience managing external academic collaborations, KOL relationships, and CROs
Experience with clinical biomarker assays (flow cytometry, ELISA, multiplex cytokine platforms, histology/IHC) and sample handling workflows
Prior experience supporting IND-enabling work is a plus
Prior experience supporting monoclonal antibody or bispecific development programs is a plus
Experience in emerging/growing companies desired

Knowledge, Skills, Abilities & Behaviors

Strong ability to interpret mechanistic data and competitive intelligence from a biology-first perspective.

Strong scientific communication skills (e.g. manuscript writing, scientific conference presentations) and ability adjust content to fit the audience (e.g. Scientists, clinical, patients, leadership)
Ability to translate mechanistic biology into practical study designs and program decisions.
Highly collaborative, diplomatic, and able to influence without direct authority.
Enjoys working in a fast-paced biotech environment
Composed and effective problem-solver who can navigate through complex situations/challenges
Project management savvy (ability to keep complex external studies on track with program partners)

Work Environment

At Uniquity Bio, we believe every team member has an impact on the patients we aim to serve. We are a nimble team with a rigorous approach to drug development that requires collaboration and transparency to maximize value, reduce risk, and deliver meaningful, best-in-class products. We are looking for self-starters who enjoy working in a complex, collaborative environment and are motivated to bring critical new medicines to people around the world. We are a small, fast-paced organization with a talented team of in-house employees and external consultants. Candidates must be self-motivated and able to work both independently and collaboratively to achieve success and impact in our dynamic work environment.

This is a U.S.-based position. Team members who live within commuting distance of our Malvern, PA or San Diego, CA office locations are expected to spend time in the office, and remote employees are expected to travel to an office on a regular basis. Specific details for both local and remote staff will be discussed and agreed upon on a case-by-case basis with the employee’s manager. Business travel may be required depending upon the specific needs of the position.

The above job description is not intended to be all-inclusive. Requirements of the position may change from time to time based on business needs.

Uniquity Bio is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All employment decisions are based on business needs, job requirements, and individual qualifications, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.

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Director, Translational Medicine