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Who We Are:
At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.
What We Do:
Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)
About the Role:
We are seeking a highly motivated Scientist or Senior Scientist to join the Bioanalysis group with a strong preclinical focus, supporting early-stage biologics drug development programs. The primary responsibility of this role is ligand binding assay (LBA) development and bioanalysis for preclinical pharmacokinetic (PK) studies in rodents and non-human primates, primarily under non-regulated conditions. The position may also support regulated GLP toxicology studies and involve interaction with external CRO partners for method transfer and study execution. Experience with ADA assay development is desirable and would be considered an add-on to the primary PK-focused responsibilities._
Your Contributions (include, but are not limited to):
Develop, optimize, and qualify ligand binding assays (e.g., ELISA, MSD/ECL, Gyrolab) to support preclinical non-regulated PK studies of antibodies, bispecifics, and fusion proteins in rodents and monkeys
Perform hands-on bioanalysis of preclinical samples and ensure data quality, integrity, and scientific rigor
Author and review bioanalytical protocols, assay qualification/validation reports, and preclinical study reports
Analyze, interpret, and clearly communicate PK bioanalytical data to project and DMPK teams
Collaborate closely with DMPK, toxicology, and pharmacology groups to support study design and data interpretation
Interact with external CROs, including:
Supporting assay and method transfer
Providing technical oversight during outsourced studies
Reviewing CRO data, reports, and study documentation
Troubleshoot assay issues and continuously improve assay performance and workflows
ADA assay development and support (screening/confirmatory/titer) may be involved on selected programs and is considered a desirable add-on to the primary PK role
At the Senior Scientist level: provide technical leadership, mentor junior scientists, and contribute to preclinical bioanalytical and outsourcing strategy
Requirements:
Scientist
BS/BA degree with 2+ years of industry experience in bioanalysis OR
MS/MA degree and some experience as noted above OR
PhD or equivalent and some experience as noted above
Hands-on experience with ligand binding assay development for PK bioanalysis
Experience supporting preclinical non-regulated studies, preferably in rodents and/or non-human primates
Basic understanding of GLP principles and bioanalytical best practices
Strong experimental, data analysis, and documentation skills
Senior Scientist
BS/BA degree with 5+ years of industry experience in bioanalysis OR
MS/MA degree and 3+ years of experience as noted above OR
PhD or equivalent and some experience as noted above
Demonstrated expertise in preclinical PK LBA strategy and execution
Experience supporting GLP toxicology studies and working with quality/compliance functions
Proven experience interacting with and overseeing external CROs
Ability to work independently, lead bioanalytical efforts, and mentor junior scientists
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Neurocrine Biosciences is an EEO/Disability/Vets employer.
We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.
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The annual base salary we reasonably expect to pay is $110,800.00-$151,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.Learn more about this Employer on their Career Site
