Scientist II, Translational Medicine

Atrium is a biopharmaceutical company pioneering delivery of RNA therapeutics to the heart to transform the standard of care for people living with cardiomyopathies. Our proprietary technology leverages the targeted RNA delivery platform initially designed at Avidity, which combines the tissue selectivity of mAbs and other targeted delivery ligands with the precision of oligonucleotides.

This unique combination is designed to allow selective targeting of the underlying genetic drivers of disease that were previously undruggable. Through targeted, non-viral delivery of siRNA to cardiac tissues, our approach has the potential to overcome key limitations of nonspecific viral and nanoparticle-based delivery systems, including challenges related to tissue specificity, immunogenicity, and redosing.

Job Summary:

Atrium is seeking a highly motivated and collaborative Scientist II to join our growing Translational Medicine (TM) team. This individual will play a pivotal role in bridging the gap between discovery biology and clinical application for our lead cardiovascular programs. This is a primary laboratory role focused on developing biomarkers that evaluate target engagement, mechanism of action and predict clinical outcomes in genetically defined cardiomyopathy populations.

 Job Responsibilities:

• Translational Research & Discovery: Collaborate closely with the Research teams to design and execute in vivo and in vitro studies that elucidate mechanism of action (MOA) and disease-relevant pathways
• Biomarker Development: Lead the discovery and analytical development of tissue and circulating biomarkers (protein, nucleic acid, or metabolic) from pilot stage through to clinical readiness
• Laboratory Execution: Hands-on execution of biomarker discovery and development. Develop, optimize, and troubleshoot new assay formats to support preclinical-to-clinical translation
• Cross-Functional Collaboration: Act as the TM representative in Research workstreams, ensuring that preclinical models are designed with "clinical translatability" in mind
• External Management: Support the transfer and validation of lead biomarker assays to Contract Research Organizations (CROs) for clinical trial implementation
• Data Analysis: Collaborate with other research teams to interpret complex datasets from cardiovascular models, identifying signals that correlate with disease progression or therapeutic response.
  
  

Education and Experience Requirements:

• PhD in Cardiovascular Biology, Physiology, Molecular Biology, or a related field
• 1–3 years of relevant experience. Experience in cardiovascular diseases and/or biomarker development is highly preferred
• Technical Expertise: Proven track record in biomarker assay development (e.g., high-sensitivity ELISA, MSD, Simoa, qPCR/ddPCR, or LC-MS). 
• Experience with in vitro (cell-based) and in vivo (animal model) cardiovascular systems. 
• Familiarity with human clinical sample handling and "fit-for-purpose" assay validation
• Growth mindset: highly adaptable with a startup environment, comfortable with ambiguity, and a proactive problem-solver, strong verbal and written communication skills

What we Provide:

• The base salary range for this role is $133,000-$145,000. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.
• Atrium offers competitive compensation and benefits which include stock options, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and LTD, and unlimited of time off including spring, summer & winter breaks
• A commitment to learning and development which includes a variety of programming internally developed by and for Atrium employees, opportunities for job-specific training offered by industry, and an education reimbursement program.