Job Title: Senior Manager/Associate Director, Clinical Science

Location: San Diego or Remote U.S.

Job Type: Full-Time

Who We Are

Avenzo Therapeutics, Inc. (“Avenzo” or “Company”) is a clinical-stage biotechnology company focused on developing next-generation oncology therapies for patients. The Company was co-founded in 2022 by Drs. Athena Countouriotis and Mohammad Hirmand (former CEO and CMO of Turning Point Therapeutics, Inc., respectively). Our team is passionate about and committed to advancing a pipeline of potentially differentiated targeted oncology programs that make a difference in the lives of people with cancer. The Company is headquartered in San Diego, California.

Position Summary

Reporting to the Executive Director, Clinical Science, the Senior Manager/Associate Director, Clinical Science will provide scientific and clinical support for the design conduct, analysis, and reporting of clinical trials. This role contributes hands-on clinical expertise across study teams while collaborating closely across the organization to ensure high-quality scientific execution.

Essential Job Functions and Responsibilities

Serve as the Clinical Science representative on cross-functional study teams, providing scientific and clinical input to support study planning, execution, data review, and study-related decision-making
Contribute to the design and development of clinical studies, including protocol development, feasibility assessments, study-related documents, and clinical sections of regulatory submissions (e.g., INDs, Investigator's Brochures, DSURs, regulatory responses, and case report forms)
Partner with Clinical Operations, Data Management, Biostatistics, Pharmacovigilance, Regulatory Affairs, and external vendors to support study execution, protocol compliance, subject safety, and overall trial oversight
Conduct ongoing clinical review of safety and efficacy data, including data trend analysis, signal identification, assessment of data quality and completeness, and communication of observations and recommendations to study teams
Support safety monitoring activities through participation in safety review meetings, Data Monitoring Committees, review of safety narratives and safety-related documents, and collaboration with Medical Monitoring and Pharmacovigilance colleagues
Develop and review study training materials and support investigator meetings, site initiation visits, and other study-related training and communication activities
Author and review clinical narratives, support data review and study closeout activities, and contribute to clinical study reports and other study deliverables
Interact with investigators, key opinion leaders, and other internal and external subject matter experts to support study conduct and ensure alignment with scientific and regulatory requirements
Contribute to study planning activities, including review of CRO deliverables, study budgets, scopes of work, and operational plans in collaboration with Clinical Operations and Clinical Outsourcing
Support scientific communications through development of presentations, abstracts, posters, publications, and other internal and external materials
Review scientific literature, emerging clinical data, and competitive intelligence to support study execution and clinical development activities

Preferred Qualifications

Bachelor’s degree required, advanced medical or life sciences or a related area degree preferred (e.g., MS, Ph.D., MPH, PharmD) with 6+ years of experience in the life sciences industry or an equivalent combination of academic and industry experience
Experience conducting clinical data listing reviews and demonstrating familiarity with standard clinical and regulatory references (e.g., CTCAE, MedDRA)
Working knowledge of principles and techniques of clinical data analysis and interpretation
Experience reviewing and contributing to clinical study protocols and related documents
Knowledge of GCP (Good Clinical Practice), ICH, FDA, EMA, and other relevant guidelines and regulations
Proven ability to collaborate within cross-functional teams
Ability to understand and assimilate complex scientific and clinical information.
Demonstrates initiative, strong organizational skills, and attention to detail.
Proficiency in Microsoft Word, Excel, PowerPoint, and Electronic Data Capture systems (e.g., RAVE), J-Review, or similar data review tools
Excellent communication and interpersonal skills, with the ability to collaborate effectively with internal and external stakeholders
Strong analytical and problem-solving abilities, with a strategic mindset
This position requires periodic/regular travel, including up to 25% of work, time which may include overnight travel

Physical Demands and Work Environment

Physical Demands:

Constant or continuous use of a computer keyboard, monitor, and mouse to perform a variety of tasks
Constant or frequent sitting, standing, or walking
May lift and/or move objects of various weights

Work Environment:

Remote: Home office; expected to travel to and work from the Company’s headquarters in San Diego from time to time
San Diego-based: On-site requirement (Monday through Thursday)
Noise level in the work environment is usually moderate
Fast-paced, time sensitive environment with frequently changing priorities
Handle multiple projects simultaneously

Reasonable accommodations may be provided to enable qualified individuals with disabilities to perform the essential functions of the position.

Salary Range

The salary range for this position for a Senior Manager is $182,000 to $189,000 per year. The salary range for this position for an Associate Director is $189,000 to $196,000 per year. The final pay offered to a successful candidate will be dependent on several factors that may include, but are not limited to, the type and years of experience within the job and the industry, education, and skills and certifications.

Benefits

Provided they meet all eligibility requirements under the applicable plan documents, employees (and their eligible dependents) will be eligible to enroll in group healthcare plans that offer medical, dental, vision, and basic life and AD&D insurance. Additional benefit programs include short-term and long-term disability insurance, flexible spending accounts, health savings accounts, and voluntary insurance programs, including voluntary life, AD&D accident, and critical illness. Employees will also be able to enroll in the Company’s 401(k) plan. In addition, employees will accrue 10 hours of paid vacation time every month and accrue 1 hour of paid sick leave for every 30 hours worked. Employees also enjoy 17 paid holidays each calendar year, including a winter closure, subject to applicable Company policies. All benefits are subject to the terms and conditions of the applicable plan documents and Company policies, which may be amended from time to time.

Other Compensation

The hired candidate will be eligible to receive an annual discretionary bonus and an equity award, subject to the terms of the applicable employment agreement, plan documents, and Company policies.

The information above is intended to provide a general description of benefits and other compensation and is not a substitute for applicable plan documents or company policies.

Applications for this position are anticipated to close on September 30, 2026 . For more information about this posting, please contact careers@avenzotx.com.

Equal Employment Opportunity

Avenzo is committed to providing equal employment opportunities to all employees and applicants without regard to an individual’s actual or perceived protected characteristic or characteristics, or any combination of protected characteristics including race (including traits associated with race, such as hair texture and protective hairstyles, including braids, locks, and twists), ethnicity, religion, religious creed (including religious dress and grooming practices), color, sex (including childbirth, breast feeding, and related medical conditions), gender, gender identity or expression, sexual orientation, national origin, ancestry, citizenship status, uniformed service member and veteran status, marital status, pregnancy, age (40 and over), protected medical condition (including cancer and genetic conditions), genetic information, disability (mental and physical), reproductive health decision-making, medical leave or other types of protected leave (requesting or approved for leave under the Family and Medical Leave Act or the California Family Rights Act), the employee or their family member’s status as a victim of a qualifying act of violence, political activity or affiliation, use of cannabis off the job and away from the workplace, association with an individual who has, or is perceived to have, a protected characteristic or characteristics, or any combination of protected characteristics, or any other protected status in accordance with all applicable federal, state, and local laws.

Notice to Search Firms/Third Party Agencies

Avenzo does not accept unsolicited resumes from recruiters, employment agencies or search firms without a valid, executed search agreement in place.

Learn more about this Employer on their Career Site

Senior Mrg/Associate Dir, Clinical Science