SRA 3

Position Overview: The Gaensler Lab at UCSF is seeking a highly skilled and motivated Senior Research Associate III (SRAIII) to contribute to our translational and pre-clinical studies focused on a novel leukemia vaccine. The lab's mission is to enhance anti-leukemic immunological responses in older patients with acute myelogenous leukemia, with the ultimate goal of improving relapse-free survival rates. The successful candidate will assess immunological responses to engineered human leukemia vaccines, collaborate on mechanistic studies of the tumor microenvironment, and participate in IND related studies.

Key Responsibilities:

• Research and Validation: Validate results from basic and translational cancer research projects in cellular biology, immunology, bioinformatics, and murine models.
• Project Leadership: Take on primary research responsibility for specific projects, particularly those involving vaccine response and drug development using in vitro biochemistry and cellular experiments.
• Cell Culture and Cloning: Conduct extensive cell culture work and standard cloning procedures.
• Gene Expression and Analysis: Perform gene expression studies and western blot analysis.
• Model Development: Develop and utilize murine models for immune therapeutic strategies.
• Database Management: Establish and maintain a formal database for necessary reagents and research sample banking.
• Data Recording: Conduct experiments and accurately record critical data.
• Collaboration and Environment: Create an inclusive environment, provide academic opportunities for trainees, and encourage participation in scientific events.

Expectations for Senior Research Associate III:

• Laboratory Management: Direct the work of a medium-sized laboratory and perform specialized experimental work.
• Innovative Contributions: Make innovative contributions to experimental procedures and contribute original ideas based on scientific methodology and related research literature.
• Multi-Disciplinary Expertise: Possess expertise of scientific procedures in two or more distinct fields of science.
• Independent Work: Perform work under general supervision, with independent and innovative contributions to experimental procedures typically expected.

Required Skills and Qualifications:

• Proficiency in cell culture and cloning.
• Experience with western blotting and protein expression is considered an additional asset.
• Background in bioinformatics- single cell analysis highly desirable
• Strong background in cellular biology, immunology including flow cytometric analyses .
• Ability to manage multiple projects and work collaboratively in a dynamic research environment.

Training and Development:

• The position offers training opportunities, including presentations at local and national meetings and co-authored publications, to foster the growth and development of the next generation of scientists in the field.