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Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.Â
The Position
This position will involve assisting in the large scale preparation of buffers utilized for purification steps of large scale oligonucleotides. The operator must comply with GLP/GMP protocols and be able to follow all association SOPs and work instructions when performing and documenting operations.
Responsibilities
- Follow batch records, SOPs, and work instructions to detail
- Document all operations in batch records and logbooks
- Comply with GMP protocols
- Operate large scale oligonucleotide manufacturing equipment (i.e. buffer prep tanks, HMIs, oligonucleotide synthesizer, purification skid, tangential flow filtration system, lyophilizer, ChemGlass reactors, pH/conductivity meters, peristaltic pumps, etc.)
- Assist other chemists as needed within the Manufacturing group during synthesis and purification of oligonucleotides including:
- Reagent solution preparation
- Mobile phase preparation
- Column Packing
- Fraction collection
- Communicate with cross-functional groups such as Process Development, Analytical Development, Quality Control, Quality Assurance, etc.
- Maintain a clean work space
- Maintain safety by wearing required personal protective equipment
- Track and update raw material usage in D365 ERP software
Requirements
- Bachelor's degree in a scientific field OR appropriate work experienceÂ
- 0 - 2 years experience in a similar position
- Excellent oral and written communication skills
- Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environment
Preferred
- Experience working in a GMP setting with controlled documentation
Arrowhead provides competitive salaries and an excellent benefit package.  Â
Candidates must have current, valid authorization to work in the country where this role is located.
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